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Published May 2011 | Accepted Version
Journal Article Open

Molecular Mechanism of Co-translational Protein Targeting by the Signal Recognition Particle


The signal recognition particle (SRP) is a key component of the cellular machinery that couples the ongoing synthesis of proteins to their proper localization, and has often served as a paradigm for understanding the molecular basis of protein localization within the cell. The SRP pathway exemplifies several key molecular events required for protein targeting to cellular membranes: the specific recognition of signal sequences on cargo proteins, the efficient delivery of cargo to the target membrane, the productive unloading of cargo to the translocation machinery and the precise spatial and temporal coordination of these molecular events. Here we highlight recent advances in our understanding of the molecular mechanisms underlying this pathway, and discuss new questions raised by these findings.

Additional Information

© 2011 John Wiley & Sons A/S. Received 6 June 2010, revised and accepted for publication 1 February 2011; uncorrected manuscript published online 3 February 2011; published online 25 February 2011. We thank members of the Shan Laboratory and expert reviewers for helpful comments on the manuscript. Our work is supported by the National Institute of Health (GM078024), the Burroughs Wellcome Fund, the Arnold and Mabel Beckman Foundation, the David and Lucile Packard Foundation and the Camile and Henry Dreyfus Foundation.

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Accepted Version - nihms-285827.pdf


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