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Published February 15, 2006 | Published
Journal Article Open

Improved in vivo photoacoustic microscopy based on a virtual-detector concept


Recently an in vivo high-resolution backward-mode photoacoustic microscope was developed that shows potential for applications in dermatology and related cancer research. However, the limited depth of focus of the large-numerical-aperture (NA) ultrasonic lens employed in this system causes the image quality to deteriorate significantly in the out-of-focus region. To solve this problem, we devised and explored, for the first time to our knowledge, a virtual-detector-based synthetic-aperture focusing technique, combined with coherence weighting, for photoacoustic microscopy with such a large-NA transducer. Images of phantoms show that the proposed technique improves the −6 dB−6 dB lateral resolution from 49–379 to 46–53

Additional Information

© 2006 Optical Society of America. Received July 18, 2005; revised October 18, 2005; accepted November 4, 2005; posted November 10, 2005 (Doc. ID 63562). This project was sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.

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