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Published October 1, 1963 | public
Journal Article Open

The cyclic helix and cyclic coil forms of polyoma viral DNA


The DNA extracted from polyoma virus exhibits certain properties which have not been reported for other viral base-paired DNA's. (1) The DNA renatures monomolecularly. The loss of helical configuration does not impair biological activity. Heating at 100° for 10-20 min followed by rapid cooling does not reduce the infective titer. Dulbecco has given evidence suggesting that a fraction of the polyoma DNA molecules are cyclic. (2) This form would in part account for the above properties.

Additional Information

© 1963 by the National Academy of Sciences. Communicated by R. Dulbecco, August 19, 1963. It is a pleasure to thank R.W. Watson for expert technical assistance, R.D. Bruner for helpful discussions during the preparation of the manuscript, R. Dulbecco for providing the polyoma virus, R.L. Sinsheimer and P.F. Davison for gifts of materials, and R. Dulbecco and M. Vogt for a copy of their unpublished manuscript. This work was supported in part by grants HE 03394 and GM 08812 from the U.S. Public Health Service. Contribution 3018 of Gates and Crellin Laboratories of Chemistry. The article includes an appendix by Walther Stoeckenius.


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