Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy
Photoacoustic microscopy (PAM) has been used to obtain high-resolution, noninvasive images of the in vivo mouse brain. In this work, we exploit the high-depth and temporal resolutions of PAM to noninvasively image the blood-oxygenation dynamics of multiple cortex vessels in the mouse brain simultaneously in response to controlled hypoxic and hyperoxic challenges. These results confirm the ability of PAM to track blood oxygenation in the mouse brain, a critical aspect of imaging brain activity through the hemodynamic response.
Additional Information© 2009 SPIE. Paper 08363LR received Oct. 8, 2008; revised manuscript received Jan. 9, 2009; accepted for publication Jan. 10, 2009; published online Mar. 13, 2009. This work was sponsored by NIH Grants No. R01 EB000712 and No. R01 NS46214.
Published - 020502_1.pdf