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Published June 2015 | public
Journal Article Open

Digital pathology with Fourier ptychography


Fourier ptychographic microscopy (FPM) is a recently introduced method of acquiring high-resolution, wide field of view (FOV) giga-pixel histology images. The FPM procedure first acquires a sequence of low-resolution images of a sample under variable-angle illumination. It then combines these images using a novel phase retrieval algorithm to improve the employed microscope's resolution beyond its conventional limit. Here, we first describe how FPM's resolution improvement can enhance wide FOV histology imaging. Second, we show that FPM also records a thin sample's optical phase, which can help pathologists digitally extract as much information as possible from a given histology slide.

Additional Information

© 2014 Elsevier Ltd. Received 27 March 2014; Received in revised form 28 May 2014; accepted 10 November 2014. We acknowledge funding support from the National Institutes of Health 1DP2OD007307-01 and Clearbridge Biophotonics (Singapore).

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Accepted Version - nihms646803.pdf


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August 22, 2023
August 22, 2023