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Published December 2017 | public
Journal Article

Bone CLARITY reveals that anti-sclerostin antibody penetrates the lacunar canalicular system in mice under physiological loading conditions


Anti-sclerostin antibody (Scl-Ab) neutralizes sclerostin activity, a secreted protein from osteocytes, resulting in WNT mediated increases in bone formation and decreases in bone resorption; this dual effect on bone results in rapid increases in bone mass and strength.

Additional Information

© 2017 American Society for Bone and Mineral Research. First published: 28 December 2017. Disclosures: Alon Greenbaum, AMGEN, Grant/Research Support.

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October 18, 2023