A cargo-sorting DNA robot

Creators: Thubagere, Anupama J.; Li, Wei; Johnson, Robert F.; Chen, Zibo; Doroudi, Shayan; Lee, Yae Lim; Izatt, Gregory; Wittman, Sarah; Srinivas, Niranjan; Woods, Damien; Winfree, Erik; Qian, Lulu

Abstract

Single-stranded DNA robots can move over the surface of a DNA origami sheet and sort molecular cargoes. Thubagere et al. developed a simple algorithm for recognizing two types of molecular cargoes and their drop-off destinations on the surface (see the Perspective by Reif). The DNA robot, which has three modular functional domains, repeatedly picks up the two types of molecules and then places them at their target destinations. No additional power is required because the DNA robot does this by random walking across the origami surface.

Additional Information

© 2017 American Association for the Advancement of Science. We thank R. Murray, P. Rothemund, C. Thachuk, P. Yin, and R. Jungmann for discussions and suggestions. Z.C., S.D., Y.L.L., G.I., and S.W. were supported by Caltech Summer Undergraduate Research Fellowships. N.S., D.W., and E.W. were supported by an NSF Expedition in Computing (0832824). A.J.T. was supported by an NSF grant (1351081). W.L. was supported by an NSF Expedition in Computing (1317694). R.F.J. was supported by an NSF Graduate Research Fellowship. L.Q. was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund (1010684) and a Faculty Early Career Development Award from the NSF (1351081). All data are reported in the main text and the supplementary materials.

Attached Files

Supplemental Material - aan6558_Thubagere_SM.pdf

Files

aan6558_Thubagere_SM.pdf

Files (12.4 MB)

Name	Size	Download all
aan6558_Thubagere_SM.pdf md5:eb1fe3995988d23e688b8907cdb0c8db	12.4 MB	Preview Download

Additional details

	All versions	This version
Views	0	0
Downloads	0	0
Data volume	0 Bytes	0 Bytes