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Published July 7, 2008 | Published
Journal Article Open

Pulsed ultrasound-modulated optical tomography using spectral-hole burning as a narrowband spectral filter


We applied a submegahertz nonlinear optical filter afforded by a cryogenically cooled spectral-hole burning crystal to ultrasound-modulated optical tomography. Our experimental results show that this technique, having the largest etendue among all available ultrasound-modulated optical tomography techniques and being immune to speckle decorrelation, offers potential for imaging in vivo and forming high resolution optical tomograms in real time. It opens an opportunity for the development of a clinically applicable high resolution optical imaging modality.

Additional Information

© 2008 American Institute of Physics. Received 21 February 2008; accepted 2 June 2008; published online 11 July 2008. This research was supported by the US National Institutes of Health Grant No. R33 CA 094267.

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