Published February 5, 2016
| Version Accepted Version + Supplemental Material
Journal Article
Open
Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis
Abstract
An asymmetric decarboxylative C_(sp)^3–C_(sp)^2 cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant α-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.
Additional Information
© 2016 American Chemical Society. Received: December 19, 2015. Publication Date (Web): February 5, 2016. J. Am. Chem. Soc., Article ASAP. Financial support was provided by the NIH (NIGMS R01 GM093213 and R01 GM062871) and by gifts from Merck and Amgen. Z.Z. is grateful for a postdoctoral fellowship from the Shanghai Institute of Organic Chemistry. Z.Z. and H.C. contributed equally to this work. The authors declare no competing financial interest.Attached Files
Accepted Version - nihms777185.pdf
Supplemental Material - ja5b13211_si_001.cif
Supplemental Material - ja5b13211_si_002.pdf
Files
ja5b13211_si_002.pdf
Additional details
Identifiers
- PMCID
- PMC4862596
- Eprint ID
- 64492
- Resolver ID
- CaltechAUTHORS:20160216-091421574
Funding
- NIH
- R01 GM093213
- NIH
- R01 GM062871
- Shanghai Institute of Organic Chemistry (SIOC)
- Merck
- Amgen
Dates
- Created
-
2016-02-17Created from EPrint's datestamp field
- Updated
-
2022-05-10Created from EPrint's last_modified field