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Published February 23, 2009 | Published
Book Section - Chapter Open

Epithelial cancer detection by oblique-incidence optical spectroscopy


This paper presents a study on non-invasive detection of two common epithelial cancers (skin and esophagus) based on oblique incidence diffuse reflectance spectroscopy (OIDRS). An OIDRS measurement system, which combines fiber optics and MEMS technologies, was developed. In our pilot studies, a total number of 137 cases have been measured in-vivo for skin cancer detection and a total number of 20 biopsy samples have been measured ex-vivo for esophageal cancer detection. To automatically differentiate the cancerous cases from benign ones, a statistical software classification program was also developed. An overall classification accuracy of 90% and 100% has been achieved for skin and esophageal cancer classification, respectively.

Additional Information

© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank the staff of the Skin Cancer and Melanoma Center (UTMDACC) and the Division of Gastroenterology and Hepatology (Mayo Clinic) for their help during the data collection. This project is sponsored by NIH grant R01 CA106728.

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