NADH Analogues Enable Metal‐ and Light‐Free Decarboxylative Functionalization
Creators
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1.
Henan Institute of Science and Technology
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2.
Henan Normal University
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3.
Institut Català d'Investigació Química
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4.
California Institute of Technology
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5.
Tsinghua University
Abstract
Here we report a metal‐ and light‐free decarboxylative functionalization approach enabled by reduced nicotinamide adenine dinucleotide (NADH) analogues. The efficient and operationally simple approach, conducted in 5 minutes from in‐situ preparation of aryliodine (III) dicarboxylates under open‐air and ambient conditions, enables diverse bond formation and exhibits a broad substrate scope of over 70 examples. Late‐stage functionalization of drug molecules and natural products further demonstrates the synthetic utility of this method. Combined experimental and computational studies elucidate the mechanistic pathway. These transformations streamline the synthesis of sp3 carbon‐enriched compounds, adding a new dimension to classical decarboxylative reactions.
Copyright and License
© 2024 Wiley-VCH GmbH
Funding
We are grateful for the financial support from the National Natural Science Foundation of China (No. 22071046, H.-M.G.; and U22A20378, H.-M.G.), the Spanish MCIN/AEI programme (No.CEX2019-000925-S, Y.L.), the Natural Science Foundation of Henan Province (No. 222300420442, H.-Y.N.) and the Key Project of Science and Technology Program of Henan Province (No. 242102311216, L.L.) for support.
Supplemental Material
Supporting Information: anie202415131-sup-0001-misc_information.pdf
Files
anie202415131-sup-0001-misc_information.pdf
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Additional details
Dates
- Accepted
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2024-11-25Accepted manuscript online
- Available
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2024-12-13Version of record online
- Available
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2025-01-15Issue online