CaltechAUTHORS
Published December 2023 | Version Published
Journal Article Metadata-only

Engineered organoids for biomedical applications

Creators

  • 1. ROR icon Terasaki Foundation
  • 2. ROR icon California Institute of Technology
  • 3. ROR icon Ghent University Hospital
  • 4. ROR icon Royal Institute of Technology
  • 5. ROR icon State University of Campinas
  • 6. ROR icon Amirkabir University of Technology
  • 7. ROR icon California State University, Northridge
  • 8. ROR icon São Paulo State University
  • 9. ROR icon University of Veterinary Medicine in Košice
  • 10. ROR icon University of Victoria
  • 11. ROR icon Instituto Butantan
  • 12. ROR icon Universidade de São Paulo
  • 13. ROR icon Pohang University of Science and Technology
  • 14. ROR icon Korea University

Abstract

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications. With their potential for personalized therapeutic interventions and high-throughput drug screening, organoids have gained significant attention recently. In this review, we discuss the latest developments in engineering organoids and using materials engineering, biochemical modifications, and advanced manufacturing technologies to improve organoid culture and replicate vital anatomical structures and functions of human tissues. We then explore the diverse biomedical applications of organoids, including drug development and disease modeling, and highlight the tools and analytical techniques used to investigate organoids and their microenvironments. We also examine the latest clinical trials and patents related to organoids that show promise for future clinical translation. Finally, we discuss the challenges and future perspectives of using organoids to advance biomedical research and potentially transform personalized medicine.

Copyright and License

© 2023 Elsevier.

Acknowledgement

The authors acknowledge funding from the National Institutes of Health (HL140951, HL137193, CA257558) and the Terasaki Institute for Biomedical Innovation. This review is also supported by the U.S. NASA MUREP Institutional Research Opportunity (MIRO) (80NSSC19M0200) and NASA MUREP High Volume (80NSSC22M0132). H-J.K. would like to acknowledge the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (RS-2023-00240729). This research was supported by the MSIT (Ministry of Science and ICT), Korea, under the ITRC (Information Technology Research Center) support program (IITP-2023-RS-2023-00258971) supervised by the IITP (Institute for Information & Communications Technology Planning & Evaluation). This work was also supported and grant-funded by Korea University Guro Hospital (Korea Research-Driven Hospital) and Korea University (K2325651). M.A. would like to acknowledge the Natural Sciences and Engineering Research Council of Canada - NSERC (RGPIN-2023-05444).

Contributions

Natan Roberto de Barros and Canran Wang contributed equally to this work.

Data Availability

No data was used for the research described in the article.

Conflict of Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional details

Identifiers

PMCID
PMC10842104

Funding

National Institutes of Health
HL140951
National Institutes of Health
HL137193
National Institutes of Health
CA257558
Terasaki Foundation
National Aeronautics and Space Administration
80NSSC19M0200
National Aeronautics and Space Administration
80NSSC22M0132
National Research Foundation of Korea
RS-2023-00240729
Ministry of Science and ICT
IITP-2023-RS-2023-00258971
Korea University
K2325651
Natural Sciences and Engineering Research Council
RGPIN-2023-05444