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Published July 7, 2008 | Accepted Version + Published
Journal Article Open

In vivo burn imaging using Mueller optical coherence tomography


We report on the use of a high-speed, fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation for in vivo burn depth evaluation and healing monitoring. A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm. In vivo burn imaging was demonstrated on porcine skin at different stages of the wound healing process, where porcine skin was used because of its similarity to the human skin. Thermally damaged region was clearly localized in the depth-resolved phase retardation image extracted from the measured Jones matrix. The burn areas in the OCT images agreed well with the histology. By using a decomposition algorithm developed by our group, we also mapped the local birefringence of the skin. The experimental results demonstrate the system's potential for in vivo burn-depth determination.

Additional Information

© 2008 Optical Society of America. Received 7 Mar 2008; revised 16 May 2008; accepted 16 May 2008; published 26 Jun 2008. This project was sponsored in part by the Department of the Army (Cooperative Agreement Number: DAMD17-97-2-7016) and the National Institutes of Health (R01 CA092415). The content of the information presented in this paper does not necessarily reflect the position or the policy of the government or NMTB. No official endorsement should be inferred.

Attached Files

Published - oe-16-14-10279.pdf

Accepted Version - nihms-1067736.pdf


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