Published January 12, 2017
| Version Accepted Version
Journal Article
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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology
Abstract
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.
Additional Information
© 2017 Elsevier Inc. Available online 12 January 2017. We apologize to the many hundreds of colleagues over the past 30 years whose work has created this rich tapestry of science but could not be cited due to space limitations. We thank Sankar Ghosh for critically reading the manuscript. This work was supported by the Intramural Research Program of the NIAID, NIH. Author Contributions: Q.Z., M.J.L., and D.B. were involved in conceptualizing, researching, and writing this review.Attached Files
Accepted Version - nihms836522.pdf
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Additional details
Identifiers
- PMCID
- PMC5268070
- Eprint ID
- 73612
- DOI
- 10.1016/j.cell.2016.12.012
- Resolver ID
- CaltechAUTHORS:20170123-094833526
Funding
- NIH
Dates
- Created
-
2017-01-26Created from EPrint's datestamp field
- Updated
-
2022-04-06Created from EPrint's last_modified field