Retzius cells retain functional membrane properties following 'ablation' by the neurotoxin 5,7-DHT
The neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) is generally believed to selectively ablate serotonergic neurons. Serotonin-containing Retzius cells (RZ) in the leech appear ablated by 5,7-DHT treatment. However, these brown, mis-shapen, non-fluorescent neurons retain their synaptic inputs, action potentials, electronic outputs, a membrane receptor, and axonal projections.
© 1984 Published by Elsevier B.V. Accepted 17 January 1984. We thank C, G. Marshall for helpful comments. Supported by PHS Grant NS-14482 to C.M.L.