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Published February 1, 2017 | metadata_only
Journal Article

Investigation of the influence of viscoelasticity on oncotripsy


Oncotripsy has recently been proposed as a means of selectively targeting cancer cells via resonant harmonic excitation (Heyden and Ortiz, 2016). The method makes use of aberrations in material properties of cancerous cells which allow to induce local resonance up to membrane lysis in cancerous cells while leaving healthy cells intact. Here, we explore the influence of viscoelasticity on the oncotripsy effect. Based on Rayleigh damping, we derive viscoelastic target frequencies and simulate the fully nonlinear transient response of healthy and cancerous cells at resonance. Results confirm the viability of oncotripsy with viscoelastic material behavior of cell constituents accounted for.

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© 2016 Elsevier B.V. Available online 1 September 2016.

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August 22, 2023
August 22, 2023