Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published April 25, 2005 | Published
Book Section - Chapter Open

Advances in high-resolution ultrasound-modulated optical tomography in biological tissues


We present an extension of our work on implementation of high-resolution ultrasound-modulated optical tomography that, based on optical contrast, can image several millimeters deep into soft biological tissues. A long-cavity confocal Fabry-Perot interferometer, which provides a large etendue and a short response time, was used to detect the ultrasound-modulated coherent light that traversed the scattering biological tissue. Using 15-MHz ultrasound, light absorbing structures placed >3 mm below the surface of chicken breast tissue were imaged with high contrast. The resolutions along the axial and lateral directions with respect to the ultrasound propagation direction were better than 70 um and 120 um, respectively. The resolutions can be scaled down further by using higher ultrasound frequencies. This technology is complementary to other imaging technologies, such as confocal microscopy and optical-coherence tomography, and has potential for broad biomedical applications.

Additional Information

© 2005 Society of Photo-optical Instrumentation Engineers (SPIE). We thank J. Li and K. Maslov for their fruitful scientific discussions. This research was supported by the National Institute of Health.

Attached Files

Published - 174.pdf


Files (496.8 kB)
Name Size Download all
496.8 kB Preview Download

Additional details

August 19, 2023
January 14, 2024