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Published September 2004 | public
Journal Article

Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain


This study demonstrates the feasibility of using nanoshells in vivo as a new contrast-enhancing agent for photoacoustic tomography. Deep penetrating near-infrared light was employed to image the in vivo distribution of poly(ethylene glycol)-coated nanoshells circulating in the vasculature of a rat brain. The images, captured after three sequential administrations of nanoshells, present a gradual enhancement of the optical absorption in the brain vessels by up to 63%. Subsequent clearance of the nanoshells from the blood was imaged for ∼6 h after the administrations.

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© 2004 American Chemical Society. Received June 8, 2004. Publication Date (Web): August 10, 2004.

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