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Published July 1997 | public
Journal Article

Cellular and molecular biology of neural crest cell lineage determination


The past few years have seen an explosion of information about genes that control the development of the neural crest, a structure unique to vertebrate embryogenesis. Many of these genes are mutated in human diseases that affect crest-derived lineages. At the same time, decades of work on the neural crest at the cellular level are generating new insights into the segregation of different lineages and the role played by environmental signals in the lineage-commitment process. The challenge now is to integrate the cellular and molecular genetic perspectives on neural crest development. This review attempts such a synthesis.

Additional Information

© 1997 Elsevier Science. Available online 10 December 1997. Work described from the author's laboratory was supported by the NIH, Muscular Dystrophy Association and the Howard Hughes Medical Institute. I thank members of my laboratory for helpful discussions, and Nirao Shah for the preparation of Fig.1

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August 19, 2023
October 20, 2023