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Published August 24, 2010 | Supplemental Material + Accepted Version
Journal Article Open

In Vivo Molecular Photoacoustic Tomography of Melanomas Targeted by Bioconjugated Gold Nanocages


Early diagnosis, accurate staging, and image-guided resection of melanomas remain crucial clinical objectives for improving patient survival and treatment outcomes. Conventional techniques cannot meet this demand because of the low sensitivity, low specificity, poor spatial resolution, shallow penetration, and/or ionizing radiation. Here we overcome such limitations by combining high-resolution photoacoustic tomography (PAT) with extraordinarily optical absorbing gold nanocages (AuNCs). When bioconjugated with [Nle^4,D-Phe^7]-α-melanocyte-stimulating hormone, the AuNCs can serve as a novel contrast agent for in vivo molecular PAT of melanomas with both exquisite sensitivity and high specificity. The bioconjugated AuNCs enhanced contrast ∼300% more than the control, PEGylated AuNCs. The in vivo PAT quantification of the amount of AuNCs accumulated in melanomas was further validated with inductively coupled plasma mass spectrometry (ICP-MS).

Additional Information

© 2010 American Chemical Society. Publication Date (Web): July 13, 2010. This work was supported in part by grants from National Institutes of Health (R01 EB000712, R01 EB008085, and U54 CA136398-the Network for Translational Research-to L.V.W.). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. Y.X. thanks the National Institutes of Health for a 2006 Director's Pioneer Award (DP1 OD000798-04). E.C.C. was also partially supported by a fellowship award from the Korea Research Foundation (KRF-2007-357-D00070) funded by the Korean Government. J.C. was supported by a Pilot Grant from Washington University Molecular Imaging Center.

Attached Files

Accepted Version - nihms-221067.pdf

Supplemental Material - nn100736c_si_001.pdf

Supplemental Material - nn100736c_si_002.avi


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August 22, 2023
October 20, 2023