S1
Supporting Information
for
Using Metal Complex Reduced States
to Monitor the Oxidation of DNA
Eric D. Olmon,
†
Michael G. Hill,
‡
and Jacqueline K. Barton*
,†
†
Division of Chemistry and Chemical Engineering, California Institute
of Technology
Pasadena, California 91125, USA;
‡
Department of Chemistry, Occidental College
Los Angeles, California 90041, USA; *To whom correspondence should be addressed:
Email jkbarton@caltech.edu
Contents
Figure S1: Cyclic voltammetry traces for
Re
and Re-OEt in acetonitrile.
Figure S2: Accumulation of guanine damage with irradiation time.
S2
Figure S1
. Cyclic voltammograms for 20
M [Re(CO)
3
(dppz)(py
′
-OH)]
+
(top) and 20
M [Re(CO)
3
(dppz)(py
′
-OEt)]
+
(bottom) in acetonitrile. Samples were throroughly
degassed with N
2
prior to measurement. Measurements were made using a glassy carbon
working electrode, a Pt auxiliary electrode, and a Ag/AgCl reference e
lectrode.
[Re(CO)
3
(dppz)(py
′
-OEt)]
+
was measured in the presence of a ferrocene/ferrocenium
(Fc
+
/Fc
0
)
internal standard. A scan rate of 0.2 V/s was used.
S3
Figure S2
. Accumulation of guanine damage with irradiation time. Damage at the 3
′
and 5
′
sites of the
guanine doublet was quantified as the number of counts at those sites relati
ve to the counts per lane from
the PAGE gel (Figure 4). Sample conditions are described in the text.