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Published April 2011 | Published
Journal Article Open

Photoacoustic tomography of foreign bodies in soft biological tissue

Abstract

In detecting small foreign bodies in soft biological tissue, ultrasound imaging suffers from poor sensitivity (52.6%) and specificity (47.2%). Hence, alternative imaging methods are needed. Photoacoustic (PA) imaging takes advantage of strong optical absorption contrast and high ultrasonic resolution. A PA imaging system is employed to detect foreign bodies in biological tissues. To achieve deep penetration, we use near-infrared light ranging from 750 to 800 nm and a 5-MHz spherically focused ultrasonic transducer. PA images were obtained from various targets including glass, wood, cloth, plastic, and metal embedded more than 1 cm deep in chicken tissue. The locations and sizes of the targets from the PA images agreed well with those of the actual samples. Spectroscopic PA imaging was also performed on the objects. These results suggest that PA imaging can potentially be a useful intraoperative imaging tool to identify foreign bodies.

Additional Information

© 2011 SPIE. Paper 10536PR received Sep. 30, 2010; revised manuscript received Feb. 20, 2011; accepted for publication Mar. 2, 2011; published online Apr. 18, 2011. We are grateful to Todd N. Erpelding for experimental assistance. This work was sponsored by National Institutes of Health Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, and U54 CA136398 (Network for Translational Research). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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