Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes
Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages, with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross-sections, should be better suited for in vivo applications. In this study, we tested Au nanocages as a contrast agent for PAT. The result suggests that Au nanocages are promising contrast agents for our applications. We also present PAT results when novel, dye-containing nanoparticles are used as contrast agents.
Additional Information© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by National Institutes of Health Grant Nos. R01 CA106728 and R01 NS46214 (BRP) as well as a Director's Pioneer Award (5DP1OD000798 to Y. X.) and a grant from NSF (DMR-0451788 to Y. X.). Part of this work was performed at the UW Nanotech User Facility (NTUF), a member of the National Nanotechnology Infrastructure Network (NNIN) funded by NSF.
Published - 68560I.pdf