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Published February 10, 2005 | Published
Journal Article Open

Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography


Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

Additional Information

© 2005 Optical Society of America. Received 19 July 2004; revised manuscript received 7 October 2004; accepted 20 October 2004. This study is sponsored by the National Institutes of Health (grants R01 NS46214-01 and R01 EB000712).

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