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Published September 2011 | Published + Accepted Version
Journal Article Open

Photoacoustic tomography: fundamentals, advances and prospects


Optical microscopy has been contributing to the development of life science for more than three centuries. However, due to strong optical scattering in tissue, its in vivo imaging ability has been restricted to studies at superficial depths. Advances in photoacoustic tomography (PAT) now allow multiscale imaging at depths from sub-millimeter to several centimeters, with spatial resolutions from sub-micrometer to sub-millimeter. Because of this high scalability and its unique optical absorption contrast, PAT is capable of performing anatomical, functional, molecular and fluid-dynamic imaging at various system levels, and is playing an increasingly important role in fundamental biological research and clinical practice. This Review discusses recent technical progress in PAT and presents corresponding applications. It ends with a discussion of several prospects and their technical challenges.

Additional Information

© 2011 John Wiley & Sons. This article is published in Contrast Media and Molecular Imaging as part of the special issue on Photoacoustic Imaging, edited by Dr. Gregory Lanza, Department of Medicine, Washington University Medical Hospital. The authors thank Professor James Ballard for manuscript editing. This research was supported by the National Institutes of Health Grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049 and 5P60 DK02057933. L.V.W. has financial interest in Microphotoacoustics Inc. and Endra Inc., which, however, did not support this work.

Attached Files

Published - Yao_et_al-2011-Contrast_Media___Molecular_Imaging.pdf

Accepted Version - nihms283933.pdf


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August 19, 2023
October 20, 2023