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Published April 18, 2023 | public
Journal Article

Validation of an Accurate and Expedient Initial Rates Method for Characterizing Mechanophore Reactivity


Understanding structure–mechanochemical reactivity relationships is important for informing the rational design of new stimuli-responsive polymers. To this end, establishing accurate reaction kinetics for mechanophore activation is a key objective. Here, we validate an initial rates method that enables the accurate and rapid determination of rate constants for ultrasound-induced mechanochemical transformations. Experimental reaction profiles are well-aligned with theoretical models, which support that the initial rates method effectively deconvolutes the kinetics of specific mechanophore activation from the competitive process of nonspecific chain scission.

Additional Information

© 2023 American Chemical Society. Financial support from Caltech and an NSF CAREER award (CHE-2145791) is gratefully acknowledged. M.E.M. and A.C.O. were supported by NSF Graduate Research Fellowships (DGE-1745301). Support from a Barbara J. Burger Graduate Fellowship (M.E.M. and A.C.O.) and Institute Fellowships (A.C.O. and S.K.O.) at Caltech is also gratefully acknowledged. M.J.R. is an Alfred P. Sloan Research Fellow and a Camille Dreyfus Teacher-Scholar. The authors declare no competing financial interest.

Additional details

August 22, 2023
October 18, 2023