Topical section: embryonic models (2023) for Current Opinion in Genetics & Development
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1.
California Institute of Technology
Abstract
Stem cell-based mammalian embryo models facilitate the discovery of developmental mechanisms because they are more amenable to genetic and epigenetic perturbations than natural embryos. Here, we highlight exciting recent advances that have yielded a plethora of models of embryonic development. Imperfections in these models highlight gaps in our current understanding and outline future research directions, ushering in an exciting new era for embryology.
Acknowledgement
We acknowledge receipt of the following Grants to M.Z.-G.: NIH Pioneer Award (USA, DP1 HD104575-01), European Research Council (EU, 669198), Wellcome Trust (UK, 207415/Z/17/Z), Open Philanthropy/Silicon Valley Community Foundation (USA), Weston Havens Foundation, (USA) and NOMIS award (CH).
Data Availability
No data were used for the research described in the article.
Conflict of Interest
The authors are inventors on the following patents: 1. Patent applicant: Caltech. Inventors: Magdalena Zernicka-Goetz, Berna Sozen, and Victoria Jorgensen. Application number: 17/692,790. Specific aspect of the paper covered in patent application: Reconstructing human early embryogenesis in vitro with pluripotent stem cells. 2. Patent applicant: Caltech and Cambridge Enterprise Limited. Inventors: Magdalena Zernicka-Goetz, Gianluca Amadei, and Charlotte Handford. Application number: 63/397,630. Specific aspect of the paper covered in patent application: Synthetic embryos. 3. Patent Applicant: Caltech and Cambridge Enterprise Limited. Inventors: Magdalena Zernicka-Goetz, Bailey Weatherbee, and Carlos Gantner. Application number: 63/403,684. Specific aspect of the paper covered in patent application: Stem cell-derived model of the human embryo.
Additional Information
This review comes from a special themed issue on Early embryonic development models, Edited by Miguel Esteban and Jose Polo.
https://www.sciencedirect.com/journal/current-opinion-in-genetics-and-development/special-issue/10V31ZD4PT8
Files
The record is publicly accessible, but files are restricted to users with access.
Additional details
- Wellcome Trust
- Weston Havens Foundation
- Valley Community Foundation
- European Research Council
- 669198
- International Human Frontier Science Program Organization
- National Institutes of Health
- DP1 HD104575-01
- Available
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2023-12-05Published online
- Publication Status
- Published