Implantable Flexible-Coiled Wireless Intraocular Pressure Sensor
This work presents an implantable wireless passive pressure sensor for long-range continuous intraocular pressure (IOP) monitoring of glaucoma patients. The sensor is microfabricated with use of parylene C (poly-chloro-p-xylylene) to create a flexible coil substrate that can be folded during implantation for suture-less minimally invasive surgery, while stretched back without damage for enhanced inductive sensor-reader coil coupling and the corresponding sensing signal. Extensive device characterizations including on-bench testing and in vivo and ex vivo animal studies verify the device feasibility in both engineering (1 mmHg pressure sensing accuracy and 2 cm sensing distance) and surgical (robust fixation to the iris and long-term biocompatibility in the intraocular environment) aspects, all meeting specifications for future practical implementation of such IOP sensing technology.
Additional Information© 2009 IEEE. This work was supported in part by Bausch and Lomb. The authors especially thank Dr. Wen Li for her assistance on data acquisition of electrical impedance measurements, Dr. Damien Roger for his comments on surgical procedures and pressure testing with animal models, and Mr. Trevor Roper for his fabrication assistance.
Published - 04805364.pdf