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Published May 1948 | Published
Journal Article Open

Growth inhibition of neurospora by canavanine, and its reversal


Canavanine, an amino acid from jack beans, was discovered by Kitagawa and coworkers in 1929 (1, 2). The substance is not combined in the proteins of the seed, but occurs in the free state, and makes up 2.5 per cent of the dry weight of jack beans (3). In a series of papers available to the authors for the most part in abstract only, the Japanese workers have reported extensive investigations into the chemistry and physiology of the substance. The structure of canavanine was established by Gulland and Morris (4) and by Kitagawa and Takani (5) as NH2•C(:NII)•NII•O•CH2•CH2•CHNH2•COOH. Natural canavanine is of the L configuration (6).

Additional Information

© 1948 American Society of Biological Chemists. Received for publication, February 4, 1948. We wish to thank Dr. G. Oppenheimer and Dr. A. J. Haagen-Smit for the microanalyses of C, H, and N. This investigation was supported by the Rockefeller Foundation and the Nutrition Foundation, Inc. [A.M.S. was a]National Research Council Fellow, 1946-47.

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August 21, 2023
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