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Introduction
Methods
Model description
Model of CaMKII monomers
Model of CaMKII holoenzyme
Rule-Based modeling and BioNetGen
Results
mCaMKII phosphorylation dose response curve depends on Ng non-linearly
Ng modulates mCaMKII phosphorylation in response to a Ca2+ spike
CaMKII holoenzyme phosphorylation is robust against fluctuations of [Ca2+]free
A leaky integrator of [Ca2+] signals
Discussion
Acknowledgments
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