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Published August 2017 | Accepted Version
Journal Article Open

Neural immunoglobulin superfamily interaction networks


The immunoglobulin superfamily (IgSF) encompasses hundreds of cell surface proteins containing multiple immunoglobulin-like (Ig) domains. Among these are neural IgCAMs, which are cell adhesion molecules that mediate interactions between cells in the nervous system. IgCAMs in some vertebrate IgSF subfamilies bind to each other homophilically and heterophilically, forming small interaction networks. In Drosophila, a global 'interactome' screen identified two larger networks in which proteins in one IgSF subfamily selectively interact with proteins in a different subfamily. One of these networks, the 'Dpr-ome', includes 30 IgSF proteins, each of which is expressed in a unique subset of neurons. Recent evidence shows that one interacting protein pair within the Dpr-ome network is required for development of the brain and neuromuscular system.

Additional Information

© 2017 Elsevier Ltd. Available online 27 May 2017. We thank Christopher Garcia, Robert Carrillo and Kaushiki Menon for discussions and R.C. and K.M. for images in Figure 2. Work in the Zinn group was supported by National Institutes of Health (NIH) grants R37 NS28182 and U01 MH109147. Work in the Özkan group was supported by NIH RO1 NS097161.

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