CaltechAUTHORS
Published September 8, 1977 | Version public
Journal Article Metadata-only

In vitro synthesis of infectious DNA of murine leukaemia virus

Creators

Abstract

DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

Additional Information

© 1977 Nature Publishing Group. Received 5 May: Accepted 20 June 1977. A preliminary account of these findings was presented at the Cold Spring Harbor meeting on RNA tumour Viruses, May 30, 1976. We would like to thank Daniel Donoghue for thoughtful advice and valuable criticism throughout this work. This research was supported by grants from the National Cancer Institute and the American Cancer Society and by a contract from the Virus Cancer Program of the National Cancer Institute. During part of this work, E.R. was supported by an NSF graduate fellowship. R.A.W. is a Cancer Research Scholar of the American Cancer Society, Massachusetts Division. D.B. is a Research Professor of the American Cancer Society.

Additional details

Identifiers

Eprint ID
74128
DOI
10.1038/269122a0
Resolver ID
CaltechAUTHORS:20170207-083820520

Funding

National Cancer Institute
American Cancer Society, Massachusetts Division
NSF Graduate Research Fellowship
NIH

Dates

Created
2017-02-07
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Updated
2021-11-11
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