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Published March 3, 2014 | Published
Book Section - Chapter Open

Focusing light in scattering media by ultrasonically encoded wavefront shaping (SEWS)


Wavefront distortion in scattering media can be compensated for using optical wavefront shaping. In this technique, a spatial light modulator (SLM) is used to apply a spatially distributed phase shift to the optical field. A genetic optimization algorithm was used to obtain the SLM pattern which best focuses light within the medium. The target volume is defined by using a focused ultrasound beam to encode light travelling within the acoustic focus. The ultrasonically-encoded light is measured and used as feedback to the algorithm, which then searches for the pattern which maximizes the encoded light intensity. We call this technique ultrasonically-encoded wavefront shaping (SEWS). Using SEWS, we focused light into a scattering medium consisting of ground glass diffuser and a gelatin phantom. The optical intensity at the target was increased by 11 times over the original intensity. These results were validated using fluorescent imaging at the ultrasonic focus.

Additional Information

© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored in part by the National Academies Keck Futures Initiative grant IS 13 and National Institute of Health grant DP1 EB016986 (NIH Director's Pioneer Award).

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