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Published November 6, 1964 | metadata_only
Journal Article

Polyoma Virus: Production in Bacillus subtilis


Particles of complete polyoma virus are produced in competent Bacillus subtilis incubated with DNA isolated from purified, conventionally grown polyoma virus. The virus grown in B. subtilis is biologically identical to polyoma virus produced by animal cells. Quantitative parameters of the system have been established, and fluctuation tests indicate that viral replication occurs within the infected bacteria.

Additional Information

© 1964 American Association for the Advancement of Science. Received 4 August 1964. Work supported by American Cancer Society grant No. E-193 and the James G. Boswell Foundation fund for Virus Research to K.E.B. and by Office of Naval Research grant Nonr-233(67) and Cancer Research Funds of the University of California to W.R.R. We thank G; Attardi, M. Delbrück, J. Weigle, and J. Vinograd for advice and materials; Mrs. A. Drew and Mrs. H. Eberle for assistance during the experimental work.

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August 19, 2023
August 19, 2023