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Published October 1, 2007 | Published
Journal Article Open

Optical coherence computed tomography


A time-resolved optical tomography, optical coherence computed tomography, is proposed to bridge the gap between diffuse optical tomography and optical coherence tomography. Both ballistic and multiple-scattered photons are measured at multiple source-detection positions by low-coherence interferometry providing a temporal resolution smaller than 100fs. A light-tissue interaction model was established using the time-resolved Monte Carlo method. The optical properties were then reconstructed by solving the inverse transient radiative transport problem under the first Born approximation. Absorbing inclusions of 100μm diameter were imaged through a 2.6-mm-thick (∼30 scattering mean-free-paths) scattering medium.

Additional Information

© 2007 American Institute of Physics. Received 16 July 2007; accepted 11 September 2007; published online 2 October 2007. We thank Dr. Youzhi Li and Dr. Ku Geng for fruitful discussion and insightful suggestions. This work was supported in part by the National Institutes of Health under Grant No. R01 CA092415 and R01 CA106728.

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