Photoacoustic tomography of water in biological tissue
As an emerging imaging technique that combines high optical contrast and ultrasonic detection, photoacoustic tomography (PAT) has been widely used to image optically absorptive objects in both human and animal tissues. PAT overcomes the depth limitation of other high-resolution optical imaging methods, and it is also free from speckle artifacts. To our knowledge, water has never been imaged by PAT in biological tissue. Here, for the first time, we experimentally imaged water in both tissue phantoms and biological tissues using a near infrared (NIR) light source. The differences among photoacoustic images of water with different concentrations indicate that laser-based PAT can usefully detect and image water content in tissue.
Additional Information© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored in part by National Institutes of Health grants R01 EB000712, EB000712A2S1, R01 EB00071207S2, R01 EB008085, R01 CA113453901, U54 CA136398, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
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