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Published July 1975 | Published
Journal Article Open

Endothelial cell junctions


In the course of a freeze-cleave study on intercellular junctions in the regenerating rat liver, we observed an unusual array of intramembranous particles located in regions of contact between endothelial cells lining the hepatic sinusoids. These arrays were characterized by an accumulation of particles which resembled a zonula occludens in their linear deployment but differed in that the contact regions were composed of individual particles which remained separated from each other by regular particle-free intervals.

Additional Information

© 1975 by The Rockefeller University Press. Received for publication 8 January 1975, and in revised form 24 March 1975. We wish to thank Dr. Elio Raviola for his continued interest and helpful advice, Dr. Morris J. Karnovsky for encouragement and support, and Mr. Robert Rubin for photographic assistance. This work was supported by United States Public Health Service Grants 5-11GM-00406 and GM-11380.

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