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Published August 15, 2007 | Published
Journal Article Open

Imaging optically scattering objects with ultrasound-modulated optical tomography


We show the feasibility of imaging objects having different optical scattering coefficients relative to the surrounding scattering medium using ultrasound-modulated optical tomography (UOT). While the spatial resolution depends on ultrasound parameters, the image contrast depends on the difference in scattering coefficient between the object and the surrounding medium. Experimental measurements obtained with a CCD-based speckle contrast detection scheme are in agreement with Monte Carlo simulations and analytical calculations. This study complements previous UOT experiments that demonstrated optical absorption contrast.

Additional Information

© 2007 Optical Society of America. Received April 24, 2007; revised June 27, 2007; accepted July 2, 2007; posted July 6, 2007 (Doc. ID 82399); published August 2, 2007. We thank A. Garcia-Uribe for measuring optical properties of the tissue phantoms. This research is supported by the National Institute of Health grants R33 CA 094267 and R01 CA106728.

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