Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 2011 | Published
Journal Article Open

Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement


This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)—the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome).

Additional Information

© 2010 Springer Science, LLC. Received: 1 June 2010. Accepted: 13 August 2010. Published online: 23 September 2010. I am extremely grateful to Ralph Adolphs for helpful comments on this review. Supported in part by grants from National Institutes of Health and the Simons Foundation.

Attached Files

Published - Paul2011p13306J_Neurodev_Disord.pdf


Files (615.8 kB)
Name Size Download all
615.8 kB Preview Download

Additional details

September 14, 2023
October 23, 2023