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Published January 10, 2012 | Published
Patent Open

Click chemistry surface functionalization for resonant micro-cavity sensors


Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.

Additional Information

Publication number US8092855B2. Publication type Grant. Application number 12/324,605. Publication date January 10, 2012 . Filing date November 26, 2008. Priority date November 28, 2007. Government Interests: STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH: The U.S. Government has certain rights in this invention pursuant to Grant No. HR 0011-04-1-0032 awarded by DARPA. Parent Case Text: RELATED APPLICATION DATA: This application claims the benefit under 35 U.S.C. .sctn.119 of U.S. Provisional Application Ser. No. 61/004,580, filed Nov. 28, 2007, the contents of which are incorporated herein by reference as though set forth in full. This application may also be related to the following applications and patent, the contents of which are also incorporated herein by reference as though set forth in full: U.S. application Ser. No. 12/243,580, filed on Oct. 1, 2008; U.S. application Ser. No. 11/733,480, filed on Apr. 10, 2007; U.S. application Ser. No. 11/016,067, filed on Dec. 17, 2004; and U.S. application Ser. No. 10/678,354, filed on Oct. 2, 2003, and U.S. Pat. No. 6,583,399, issued on Jun. 24, 2003.

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Published - US20090214755.pdf

Published - US8092855B2.pdf


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