Toward a Symphony of Reactivity: Cascades Involving Catalysis and Sigmatropic Rearrangements
Catalysis and synthesis are intimately linked in modern organic chemistry. The synthesis of complex molecules is an ever evolving area of science. In many regards, the inherent beauty associated with a synthetic sequence can be linked to a certain combination of the creativity with which a sequence is designed and the overall efficiency with which the ultimate process is performed. In synthesis, as in other endeavors, beauty is very much in the eyes of the beholder.† It is with this in mind that we will attempt to review an area of synthesis that has fascinated us and that we find extraordinarily beautiful, namely the combination of catalysis and sigmatropic rearrangements in consecutive and cascade sequences.
Additional Information© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: March 27, 2013; Published online: February 12, 2014. We thank Dr. Wen-Bo Liu and Nathan Bennett for helpful comments and editing. We also thank NIH-NIGMS (R01GM080269), Amgen, Abbott, Boehringer Ingelheim, ACS Organic Division (fellowship for J.A.M), Bristol-Meyers Squibb (fellowship for J.A.M), Pfizer-UNCF (fellowship for R.S.), and Caltech for financial support. A.C.J. thanks Wake Forest University for start-up support and NIH-NRSA (F32GM082000) for support of a postdoctoral fellowship.
Accepted Version - nihms-582830.pdf