OMTN, Volume
35
Supplemental information
Inhibition of SARS-CoV-2 growth in the lungs
of mice by a peptide-conjugated morpholino
oligomer targeting viral RNA
Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V.
Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton
Tolbert, Mario Blanco, Amy Chow, Mitchell Guttman, Cuiping Li, Yiming Bao, Joses
Ho, Sebastian Maurer-Stroh, Arnab Chatterjee, Sumit Chanda, Adolfo García-
Sastre, Michael Schotsaert, John R. Teijaro, Hong M. Moulton, and David A. Stein
Table S1
. Bioinformatic analysis of sequence agreement* between 5’END
-
2 PPMO and
SARS
-
CoV
-
2 target in Omicron genomes
from an 18 month period from April 2022
-
October 2023.
SARS
-
CoV
-
2
Sequence
collection
dates
Number
of
sequences
analyzed
% with
perfect
agreement
between
5’END
-
2
and SARS
-
CoV
-
2
% with 1
mismatch
between
5’END
-
2
and SARS
-
CoV
-
2
% with 2
mismatches
between
5’END
-
2
and SARS
-
CoV
-
2
% with 3
mismatches
between
5’END
-
2
and SARS
-
CoV
-
2
% with 4 or
more
mismatches
between
5’END
-
2
and SARS
-
CoV
-
2
April 2022
-
Sept 2022
185,638
98.08
1.5
0.18
0.1
0.13
October
2022
-
March
2023
95,430
98.25
1.33
0.15
0.09
0.19
April 2023
-
October
2023
40,585
96.85
2.36
0.26
0.03
0.5
*Based on Wuhan
-
Hu
-
1, GenBank NC_045512