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Published December 2014 | Accepted Version + Supplemental Material
Journal Article Open

Time-reversed adapted-perturbation (TRAP) optical focusing onto dynamic objects inside scattering media


The ability to steer and focus light inside scattering media has long been sought for a multitude of applications. At present, the only feasible strategy to form optical foci inside scattering media is to guide photons by using either implanted or virtual guide stars, which can be inconvenient and limits the potential applications. Here we report a scheme for focusing light inside scattering media by employing intrinsic dynamics as guide stars. By adaptively time-reversing the perturbed component of the scattered light, we show that it is possible to focus light to the origin of the perturbation. Using this approach, we demonstrate non-invasive dynamic light focusing onto moving targets and imaging of a time-variant object obscured by highly scattering media. Anticipated applications include imaging and photoablation of angiogenic vessels in tumours, as well as other biomedical uses.

Additional Information

© 2014 Macmillan Publishers Limited. Received 26 March 2014; accepted 24 September 2014; published online 2 November 2014. We thank F. Zhou for assistance on the flow-control system, L. Wang for discussion on the experimental design, Y. Zhou for assistance on the dye-solution preparation and J. Ballard for editing the manuscript. This work was supported by the National Institutes of Health grants DP1 EB016986 (NIH Director's Pioneer Award) and R01 CA186567 (NIH Director's Transformative Research Award). Author contributions: C.M. and L.V.W. initiated the project. C.M. and X.X. implemented the DOPC-based system. C.M., X.X. and Y.L. designed and ran the experiments. C.M. wrote the codes for the experiments and simulation, and processed the experimental results. L.V.W. provided overall supervision. All authors were involved in writing the manuscript. The authors declare no competing financial interests.

Attached Files

Accepted Version - nihms631046.pdf

Supplemental Material - nphoton.2014.251-s1.pdf

Supplemental Material - nphoton.2014.251-s2.mov

Supplemental Material - nphoton.2014.251-s3.mov

Supplemental Material - nphoton.2014.251-s4.mov


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August 20, 2023
October 19, 2023