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Published January 15, 2011 | Published + Accepted Version
Journal Article Open

Fast voice-coil scanning optical-resolution photoacoustic microscopy


We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9 mm range and up to 40 Hz over a 1 mm scanning range. A focused laser beam provides a lateral resolution of 3.4 μm as measured in an optically nonscattering medium. Flows of micrometer-sized carbon particles or whole blood in a silicone tube and individual red blood cells (RBCs) in mouse ear capillaries were also imaged in real time, demonstrating the capability to image highly dynamic processes in vivo at a micrometer-scale resolution.

Additional Information

© 2011 Optical Society of America. Received September 22, 2010; revised November 24, 2010; accepted November 27, 2010; posted December 13, 2010 (Doc. ID 135532); published January 6, 2011. We acknowledge the help of Li Li in the system design. This work was sponsored in part by National Institutes of Health (NIH) grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, and 5P60 DK02057933. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc.; however, neither provided support for this work.

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Published - ol-36-2-139.pdf

Accepted Version - nihms277312.pdf


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