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Published April 4, 2012 | Published
Journal Article Open

Quantitative modeling of the behaviour of microfluidic autoregulatory devices


We develop a theoretical model for a fluidic current source consisting of a via, a detour channel, and a push-up type micro-valve. The model accurately describes the non-linear behaviour of this type of device, which has been previously measured experimentally. We show how various structural parameters and material properties of the device influence the saturated flow rate and the minimum driving pressure required for the device to function as a current source. Conversely, the model can be used to design a fluidic current source with a desired saturated flow rate and low operational pressure. The present model can be straightforwardly applied to microfluidic circuits composed of many functional autoregulatory devices.

Additional Information

© 2012 The Royal Society of Chemistry. Received 04 Oct 2011, Accepted 06 Mar 2012. First published on the web 04 Apr 2012. This work was supported by National Institutes of Health grant 4R00EB007151.

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Published - Chang2012p18176Lab_on_a_Chip.pdf


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