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Published December 1970 | Published
Journal Article Open

The crystal structure of a proposed fusidic acid intermediate


The structure of a proposed intermediate in the synthesis of the abnormal steroid fusidic acid was determined by means of X-ray analysis. The compound, C_(23)H_(27)O_3Br, forms triclinic crystals, space group P1[bar], with cell dimensions a = 8.681, b = 7.361, c = 16.077 Å, α = 90.85, β = 99.44, γ = 84.97°; there are two molecules in the cell. The structure was refined to an R index of 6.3% for 1979 non-zero reflections measured on a diffractometer. The results of the analysis revealed that the proposed intermediate has a structure incompatible for conversion to the desired steroid.

Additional Information

© 1970 International Union of Crystallography. (Received 10 September 1968 and in revised form 4 August 1969) Contribution No. 3708 from the Gates and Crellin Laboratories of Chemistry. This investigation was supported in part by research grants GM 12121 from the United States Public Health Service and GB 6617X from the National Science Foundation.

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