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Published May 1, 2008 | Published
Journal Article Open

Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries


Capillaries, the smallest blood vessels, are the distal end of the vasculature where oxygen and nutrients are exchanged between blood and tissue. Hence, noninvasive imaging of capillaries and function in vivo has long been desired as a window to studying fundamental physiology, such as neurovascular coupling. Existing imaging modalities cannot provide the required sensitivity and spatial resolution. We present in vivo imaging of the microvasculature including single capillaries in mice using optical-resolution photoacoustic microscopy (OR-PAM) developed in our laboratory. OR-PAM provides a lateral resolution of 5 µm and an imaging depth >0.7 mm.

Additional Information

© 2008 Optical Society of America. Received January 30, 2008; accepted March 2, 2008; posted March 20, 2008 (Doc. ID 92316); published April 23, 2008. This research was sponsored in part by the National Institutes of Health grants R01 EB000712 and R01 NS46214 Bioengineering Research Partnership. The authors contributed equally to this work.

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