Published September 3, 2010
| Accepted Version + Supplemental Material
Journal Article
Open
Alkyl-Alkyl Suzuki Cross-Coupling of Unactivated Secondary Alkyl Chlorides
- Creators
- Lu, Zhe
-
Fu, Gregory C.
Abstract
No such thing as a problem substrate! In a reaction designed specifically for the title substrates C-C coupling with alkyl boranes occurred in good yield at room temperature with commercially available catalyst components (see scheme). This versatile method is also suitable for Suzuki reactions of secondary and primary alkyl bromides and iodides, as well as primary alkyl chlorides.
Additional Information
© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: May 30, 2010; Published online: August 16, 2010. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences, grant R01-GM62871), Eli Lilly (fellowship to Z.L.), the Martin Family Society of Fellows for Sustainability (fellowship to Z.L.), Merck Research Laboratories, and Novartis. We thank Dr. Bunnai Saito for preliminary studies and Dr. Jeffrey H. Simpson for assistance with NMR spectroscopy.Attached Files
Accepted Version - nihms257830.pdf
Supplemental Material - anie_201003272_sm_miscellaneous_information.pdf
Files
nihms257830.pdf
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Additional details
- PMCID
- PMC3073318
- Eprint ID
- 103171
- Resolver ID
- CaltechAUTHORS:20200513-100146935
- NIH
- R01-GM62871
- Eli Lilly
- Martin Family Society of Fellows for Sustainability
- Merck Research Laboratories
- Novartis
- Created
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2020-05-13Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field