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Published September 10, 1987 | public
Journal Article

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme


The RAD6 gene of the yeast Saccharomyces cerevisiae is required for a variety of cellular functions including DNA repair. The discovery that the RAD6 gene product can catalyse the covalent attachment of ubiquitin to other proteins suggests that the multiple functions of the RAD6 protein are mediated by its ubiquitin-conjugating activity.

Additional Information

© 1987 Nature Publishing Group. Received 25 June; accepted 17 July 1987. We thank Daniel Finley for helpful discussions and advice; Paul Matsudaira for communicating his protein transfer/sequencing procedure before publication; William Lane for protein sequencing; Andreas Bachmair, Bonnie Bartel, Daniel Finley and Mark Hochstrasser for comments on the manuscript; and Barbara Doran for secretarial assistance. This work was supported by a grant to A.V. from the National Institute of General Medical Sciences. S.J. was supported by a fellowship from the Deutsche Forschungsgemeinschaft.

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