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Published February 18, 1994 | metadata_only
Journal Article

Paralysis and Early Death in Cysteine String Protein Mutants of Drosophila


Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.

Additional Information

© 1994 American Association for the Advancement of Science. Received 16 September 1993; accepted 18 January 1994. We acknowledge the assistance of S. Ou and P. Patterson of the Caltech monoclonal antibody facility in providing the mAbs and E. Schwarz for the Northern blots. The "site-directed P-mutagenesis" was performed by two of us (K.K.E. and N.W.) in the laboratories of E. Hafen and M Noll at the University of Zurich. The technical assistance of M. Jenni, O. Zilian (Zurich), N. Krejci, and Y. Schleger of the Buchner laboratory and R. Young, L. Dowling, C. Pham, and E. Eichenberger of the Benzer laboratory is acknowledged. We thank the other members of the Benzer group for their critical comments on the manuscript. Supported by a fellowship to K.E.Z. and by grants to E.B. from the Deutsche Forschungsgemeinschaft and by grants to S.B. from the NSF, the National Eye Institute of the NIH, and the James G. Boswell Foundation.

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August 20, 2023
August 20, 2023